GLP-1 receptor agonists are most often discussed in the context of weight loss. However, growing evidence shows they can also support cardiovascular health. For providers interested in offering compounded semaglutide and tirzepatide, understanding these added benefits can help shape patient selection and treatment goals.
Vigor Compounding is a 503A compounding pharmacy focused exclusively on GLP-1 weight loss therapies. We work directly with medical providers, offering a clinically aligned and pharmacy-driven partnership for practices that want to integrate GLP-1 therapies into their patient care models.
GLP-1s and Heart Health: What the Data Shows
GLP-1 receptor agonists mimic natural incretin hormones that regulate blood sugar and appetite. These medications slow gastric emptying, reduce food intake, and support insulin secretion.
In addition to metabolic improvements, they have been shown to reduce key cardiovascular risk factors. This includes systolic blood pressure, LDL cholesterol, and inflammatory markers such as C-reactive protein.
A study published by the New England Journal of Medicine evaluated patients with type 2 diabetes and high cardiovascular risk. Those who received semaglutide once a week demonstrated reduced rates of major adverse cardiovascular events (MACE), including stroke and myocardial infarction.
Another study published by The Lancet assessed individuals who were overweight or obese with established cardiovascular disease (but did not have diabetes). This study showed a 20 % reduction in MACE when patients were treated with semaglutide compared to a placebo.
These findings suggest a potential cardioprotective effect, especially for patients with obesity, insulin resistance, or metabolic syndrome.
Clinical Relevance for Providers Prescribing GLP-1 Therapies
For patients with excess weight and a history of cardiovascular disease — or risk factors like hypertension or dyslipidemia — GLP-1 therapy may support more than weight loss alone. Providers can consider these agents as part of a comprehensive approach to mitigate long-term health risks.
When discussing treatment options, patients often focus on pounds lost. Framing the conversation around improved heart health, blood pressure control, and inflammatory regulation can help them understand the full benefit of staying consistent with treatment.
Partner With a Compounding Pharmacy That Prioritizes Outcomes
Given limited access to commercial GLP-1 drugs, compounding therapies have become a practical alternative. Partnering with a trusted 503A pharmacy like Vigor Compounding gives providers control over the prescribing process and confidence in consistent product quality.
If you’re ready to offer compounded GLP-1 therapy to your patients, Vigor Compounding can help you get started. Reach out today to discover how to incorporate GLP-1 therapies into your treatment protocols.
