Semaglutide and tirzepatide have become cornerstone therapies in treating obesity and metabolic syndrome. Not all patients respond to these medications the same way, though.
Vigor Compounding – a 503A compounding pharmacy specializing in GLP-1 medications – compounds semaglutide and tirzepatide with vitamin B6 (pyridoxine) with the goal of increasing patient comfort and improving clinical results.
Why does this one vitamin make such a difference? Learn why we add B6, what the research says, and how it can benefit your patients’ experiences below.
Why Add Vitamin B6 to Compounded GLP-1s?
Nausea is one of the most common side effects associated with GLP-1 receptor agonists. For some, this can disrupt treatment continuity and lower adherence.
Vitamin B6 has long been used as a first-line intervention for nausea, particularly in pregnancy. When included in compounded GLP-1 injections, B6 may reduce:
- Nausea and vomiting
- Fatigue
- Neurological symptoms (such as neuropathy, mood changes, and difficulty concentrating)
It is thought that this addition may smooth the titration process and enhance comfort from the outset.
What the Research Suggests
Most data on vitamin B6’s antiemetic effects come from studies on nausea associated with pregnancy and chemotherapy. However, the mechanism can reasonably be applied to GLP-1 therapy.
B6’s anti-nausea benefit is tied to its role in synthesizing serotonin, dopamine, and GABA. According to the International Journal of Molecular Sciences, these neurotransmitters help regulate nausea in the central nervous system (CNS).
GLP-1 receptor agonists can trigger nausea by acting on CNS pathways. Because of this, some providers have asserted that B6 might mitigate these issues.
Individuals receiving compounded formulations with B6 may experience:
- Improved tolerability during dose escalation
- Reduced dropout rates
- Increased likelihood of sticking with long-term therapy
These advantages are still being explored in formal studies. However, they are gaining support through real-world clinical feedback.
Learn More About Compounded GLP-1 Medications With B6
Vitamin B6 might be a small addition, but it can make a meaningful difference in how people tolerate GLP-1 therapy. For practitioners prescribing compounded semaglutide or tirzepatide, choosing a formulation that includes B6 reflects a commitment to patient-centered care.
Are you interested in partnering with Vigor Compounding for compounded GLP-1 solutions that prioritize patient well-being and provider flexibility? Contact us today to learn how our semaglutide and tirzepatide formulations can support your practice.
